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There is no single drug that can effectively eliminate H. pylori and a combination of drugs is generally prescribed. Usually this is two types of antibiotics as well as a PPI (proton pump inhibitor). The PPI is used to decrease the stomach's acidity, allowing the inflamed stomach lining to heal and eradicating the bacterial infestation in the affected area. This drug combination is normally referred to as "Triple Therapy."
The duration of the therapy is usually between 10 to 14 days. There have been studies that show that shorter regimens may be effective, but they have not yet been adapted to routine clinical practice.
In approximately 80% of patients, Helicobacter pylori treatment is successful. However, if additional therapy is needed, your doctor will prescribe other drugs that have proven to be effective in treating H. pylori infections.
Individuals who have antibiotic resistant bacteria also may need additional rounds of H. pylori therapy; in some cases, alternative strategies with quadruple therapy (including bismuth colloid) may be needed. Patients may need multiple breath tests throughout the H. pylori treatment process, so that medical professionals can monitor their progress and immediately intercede with a change in medication if they are not responding as desired. Since individuals are often asymptomatic for years, accurate testing is the first step toward helicobacter pylori therapy.